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Exploring the anti-osteoarthritic effect of Hemp Tribe Orthogo granules on monosodium iodoacetate induced osteoarthritis rat model

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Original Article

Author Details : Arumugam Meena, Arumugam Shanthy, Manepalli Nageswara Rao Gupta, Gopalakrishnan Saravanan, Sallabuthula Rajkumar, Chandrasekar Leela Priyanka, Balasekar Premkumar*

Volume : 9, Issue : 4, Year : 2024

Article Page : 256-262

https://doi.org/10.18231/j.ijcaap.2024.037

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Abstract

Background: Osteoarthritis is a degenerative joint condition characterized by the deterioration of joint structures, resulting in pain and reduced joint motion. It results in joint degeneration marked by the gradual deterioration of cartilage, leading to pain and reduced joint motion. It is a debilitating disease with no available treatment, and the discovery of a medication that benefits the joints is a significant area of research.
Objectives: This study examined the anti-osteoarthritis effects of the OrthoGo formulation on monosodium Iodoacetate (MIA)-induced osteoarthritis in rats by measuring the activity of the standard painkiller Diclofenac Sodium.
Materials and Methods: Osteoarthritis models were established using the intra-articular injection of monosodium iodoacetate in rats. Following a three-week induction, measurements conducted include Eddy’s hot plate, inclined plane test, staircase ascent, and gait assessment. The impact of the preparation in mitigating the degenerative characteristics of the joints was examined via radiographic and histological analyses.
Results: The results indicated an enhancement in analgesic efficacy in Eddy's hot plate, an increased duration on the inclined plane, enhanced gait performance, and reduced degenerative alterations in animals administered OrthoGo granules.
Conclusion: The OrthoGo formulation comprises hemp seed powder, glucosamine sulfate potassium chloride, and collagen peptides, which limit the progression of osteoarthritis by delaying cartilage deterioration, reducing inflammation, and enhancing locomotor performance. Consequently, OrthoGo granules containing hemp seeds may serve as a viable treatment agent for osteoarthritis, potentially exhibiting fewer adverse effects than standard analgesics such as Diclofenac Sodium.

Keywords: Arthritis, Inflammation, Hemp, Cannabis, Analgesic, Osteocyte

How to cite : Meena A, Shanthy A, Gupta M N R, Saravanan G, Rajkumar S, Priyanka C L, Premkumar B, Exploring the anti-osteoarthritic effect of Hemp Tribe Orthogo granules on monosodium iodoacetate induced osteoarthritis rat model. IP Int J Compr Adv Pharmacol 2024;9(4):256-262

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