IP International Journal of Comprehensive and Advanced Pharmacology
Official Publication of Khyati Education And Research Foundation
Official Publication of Khyati Education And Research Foundation
Print ISSN:-2581-5555
Online ISSN:-2456-9542
CODEN : IIJCDU
Original Article
Author Details :
Volume : 8, Issue : 1, Year : 2023
Article Page : 54-58
https://doi.org/10.18231/j.ijcaap.2023.009
Abstract
The study was intended to explore the potential role of Moringa oleifera leaf extract (MOLE) on cisplatin (CIS) induced neuronal damage in experimental male rats. In the current work, animals were divided into four groups, six animals in each group. Group-1 (Normal) administered with Distilled water 1ml p.o. Group-2 (CIS) was received cisplatin 5mg/kg, ip. single dose. Group-3 (CIS + MOLE 200mg/kg) was orally administrated MOLE 200mg/kg, dissolved in water for 14 days with a cisplatin 5 mg/kg, ip. single dose on 10 day. and Group-4 (CIS + MOLE 400mg/kg) was orally administrated MOLE 400mg/kg, dissolved in water for 14 days with a cisplatin 5mg/kg, ip. single dose on 10 day. After 14 days of MOLE dosing, the rats were sacrificed after anesthetizing with ketamine. Brain of individual rat was excised and processed for evaluation of oxidative injury markers like malonyl dialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase and histopathological study. MOLE treated experimental groups explored a potential (P<0>
Keywords: Cisplatin, Oxidative stress, Neurodegeneration, Moringa oleifera leaf extract, Neuroprotective, Antioxidants, Histopathology
How to cite : Karale S, Mohammed Farshad P, Kamath J V, Moringa oleifera leaf extract ameliorates cisplatin evoked neurotoxicity in male wistar rats. IP Int J Compr Adv Pharmacol 2023;8(1):54-58
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
