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Antifertility activity of Momordica dioica and Lagerstroemia speciosa in experimental rats

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Original Article

Author Details : Krishna Patil, Manojkumar Mahajan, Aman Upaganlawar*, Chandrashekhar Upasani

Volume : 7, Issue : 2, Year : 2022

Article Page : 96-101

https://doi.org/10.18231/j.ijcaap.2022.018

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Abstract

Agents that control fertility are termed as antifertility agents or oral contraceptives. Many plant-based products have the antifertility potential which need to be explored.The present study therefore was undertaken to evaluate possible antifertility effects of hydroalcoholic extract of fruits of (HAEMD) and aqueous extract of leaves of (AELS) in experimental rats. Experiments were carried using wistar rats of either sex. Animals were administered with different doses of HAEMD and AELS (250, and 350 mg/kg, p. o) for 30 days. The body weight and reproductive organs weights for male (Testis) and for female (Uterus) were analyzed. Sperm count and Sperm motility was determined in male rats by manually. Testosterone in male and progesterone levels in female rats were checked. Effect of both extracts on Estrous cycle in female rats were checked. Section of testis were taken for histopathological study. The effect of the extract on male rats showed decreased testis weight, reduced sperm count and motility as compared to control animals. The blood testosterone level in male rats was reduced in treatment groups. The testicular histology was altered as compared to control male rats. In female animals, extracts showed antiovulatory activity, alteration in estrous cycle, decreased uterus weight and serum progesterone levels. It is concluded that HAEMD and AELS are effective as antifertility plants for both male and female rats.
 

Keywords: Antifertility, Antiovulatory, Momordica dioica, Lagerstroemia speciosa, Sperm count, Estrous cycle

How to cite : Patil K, Mahajan M, Upaganlawar A, Upasani C, Antifertility activity of Momordica dioica and Lagerstroemia speciosa in experimental rats. IP Int J Compr Adv Pharmacol 2022;7(2):96-101

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