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- DOI 10.18231/j.ijcaap.2025.011
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CrossMark
From chemistry to clinic: The transformative role of nanofibers in cancer management
- Author Details:
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Devesh U Kapoor
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Bhupendra G Prajapati *
Devesh U Kapoor
Nanofiber technology has emerged as a transformative platform in the realm of cancer therapeutics, bridging the disciplines of polymer chemistry, materials science, and biomedical engineering. This editorial highlight the multifaceted roles nanofibers play in cancer management, emphasizing how chemistry-driven design enables targeted, responsive, and sustained drug delivery systems. The editorial explores the application of nanofiber systems across diverse cancer types including brain, breast, lung, liver, colorectal, and gynaecological cancers showcasing their adaptability to organ-specific challenges and tumor microenvironments. Despite significant advancements, challenges related to scalability, regulatory approval, long-term safety, and cost-effectiveness remain.
Keywords: Nanofiber, Polymers, Drug delivery, Targeted delivery, Oncology.
References
- Chehelgerdi M, Chehelgerdi M, Allela OQB, Pecho RDC, Jayasankar N, Rao DP, et al. Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation. Mol Cancer. 2023;22(1):169.
- Wei W, Wildy M, Xu K, Schossig J, Hu X, Hyun DC, et al. Advancing nanofiber research: assessing nonsolvent contributions to structure using coaxial electrospinning. Langmuir. 2023;39(31):10881–91.
- Chen FM, Liu X. Advancing biomaterials of human origin for tissue engineering. Prog Polym Sci. 2016;53:86-168.
- Chen X, Argandona SM, Melle F, Rampal N, Fairen-Jimenez D. Advances in surface functionalization of next-generation metal- organic frameworks for biomedical applications: Design, strategies, and prospects. Chem. 2024;10(2):504-43.
- Yusuf M, Haji A. Handbook of nanofibers and nanocomposites: Characteristics, synthesis, and applications in textiles: Jenny Stanford Publishing; 2023.
- Hiwrale A, Bharati S, Pingale P, Rajput A. Nanofibers: A current era in drug delivery system. Heliyon. 2023;9(9):e18917.
- Yeganegi M, Kandel RA, Santerre JP. Characterization of a biodegradable electrospun polyurethane nanofiber scaffold: Mechanical properties and cytotoxicity. Acta Biomater. 2010;6(10):3847–55.
- Kolb HC, Finn MG, Sharpless KB. Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Angew Chem Int Ed Engl. 2001 Jun 1;40(11):2004–21.
- Yadav S, Sharma A, Kurmi BD, Kaur K, Sandhu NK, Thakur S, et al. Nanofiber drug delivery systems: recent advances in nanofabrication and their role in targeted therapy in cancer, neurodegenerative, and cardiovascular diseases. Polym Adv Technol. 2025;36(5):e70198.
- Rohde F, Danz K, Jung N, Wagner S, Windbergs M. Electrospun Scaffolds as Cell culture substrates for the cultivation of an in vitro blood-brain barrier model using human induced pluripotent stem cells. Pharmaceutics. 2022;14(6):1308.
- Zong S, Wang X, Yang Y, Wu W, Li H, Ma Y, et al. The use of cisplatin-loaded mucoadhesive nanofibers for local chemotherapy of cervical cancers in mice. Eur J Pharm Biopharm. 2015;93:127–
- Guo J, Zeng H, Chen Y. Emerging Nano Drug Delivery Systems Targeting Cancer-Associated Fibroblasts for Improved Antitumor Effect and Tumor Drug Penetration. Mol Pharm. 2020;17(4):1028–
- Persano L, Maniglio D, Tanzi MC, Nastruzzi C. Industrial upscaling of electrospinning and applications of polymer nanofibers: a review. Macromol Mater Eng. 2013;298(5):504–20.
- Tinkle S, McNeil SE, Mühlebach S, Bawa R, Borchard G, Barenholz YC, et al. Nanomedicines: addressing the scientific and regulatory gap. Ann N Y Acad Sci. 2014;1313:35–56.